Featuring a scene shot in Melrose, the ‘Beetlejuice’ sequel hits theaters on Sept. 6.

The juice is on the loose again in the new trailer for “Beetlejuice Beetlejuice,” the highly anticipated follow-up to Tim Burton’s 1988 horror comedy featuring Michael Keaton as the titular demon.

The film was partially shot in Massachusetts last year, with the bulk of the scenes filmed in Vermont. Last November, crews descended upon a Melrose neighborhood for several days to capture a scene starring Jenna Ortega. Homes along Charles and West Emerson streets were transformed with jack-o’-lanterns and skeletons for the shoot.

“Beetlejuice Beetlejuice”—the double “Beetlejuice” serves as a nod to the incantation that summons the mischievous ghoul—opens in theaters on September 6, just in time to rev up audiences for the Halloween season.

Michael Keaton as Beetlejuice in “Beetlejuice Beetlejuice.” (Parisa Taghizadeh/Warner Bros. Pictures)

Ortega portrays Astrid, daughter of Lydia Deetz (Winona Ryder reprising her role), alongside Catherine O’Hara as the fan-favorite Delia Deetz. The star-studded cast includes Justin Theroux, Monica Bellucci, Arthur Conti, and Willem Dafoe. Burton returns to direct from a screenplay by Alfred Gough and Miles Millar (“Wednesday,” starring Ortega).

The plot gets underway as three generations of the Deetz family return home to Winter River to attend the funeral of Delia’s husband, Charles Deetz (Jeffrey Jones in the first movie). Still haunted by Beetlejuice, Lydia’s life is turned upside down when her rebellious teenage daughter, Astrid, discovers the elaborate model of the town in the attic, accidentally opening the portal to the Afterlife. With trouble brewing in both realms, it’s only a matter of time until someone says Beetlejuice’s name three times, resurrecting the old trickster for another round of mirth and mayhem.

In the original film, Beetlejuice is a self-proclaimed bio-exorcist who assists a recently deceased couple in haunting the obnoxious new owners of their former home. The film won an Academy Award for Best Makeup.